PROfiling Based Endometrial Cancer Adjuvant Therapy

This study is testing a personalized approach to deciding which type of follow-up treatment (radiation, chemotherapy, or observation) is best for women with early-stage endometrial (uterine) cancer after surgery, based on the tumor's molecular profile. **You may be eligible if:** - You have been diagnosed with early-stage endometrial cancer (stage IA grade 3, stage IB grade 1–3, or stage II), confirmed by biopsy - You have undergone a hysterectomy (uterus removal), removal of fallopian tubes, and lymph node assessment - You are in reasonably good health (WHO performance status 0–2) - You are able to give written informed consent **You may NOT be eligible if:** - There is remaining cancer after surgery - You have a different type of endometrial cancer (such as serous, clear cell, or undifferentiated) - You have had a prior cancer (except certain early-stage skin cancers) - You have had prior pelvic radiation - More than 8 weeks have passed since your surgery Talk to your doctor to see if this trial is right for you.