RecruitingPhase 2NCT05181891

Pharmaceutically-Enhanced Reinforcement for Reduced Alcohol and Smoking

Sponsor

Washington State University

Enrollment

205 participants

Start Date

Jul 11, 2022

Study Type

INTERVENTIONAL

Conditions

Nicotine Use Disorder Alcohol Use Disorder (AUD)

Summary

Using a randomized controlled trial (RCT), the goal of this study is to evaluate the ability of evidence based behavioral treatment (contingency management: CM) to significantly decrease alcohol use and cigarette smoking among treatment-seeking smokers with an alcohol use disorder (AUD) who have initiated pharmacotherapy (varenicline; VC) for smoking cessation.

Eligibility

Min Age: 18 Years

Inclusion Criteria11

4 or more standard drinks on the same occasion for women (5 or more standard drinks on the same occasion for men) on at least 4 occasions in the prior 30 days
Seeking AUD treatment
Seeking smoking cessation treatment
Aged 18+ years
DSM-5 diagnosis of AUD
Currently smoking daily according to PhenX Smoking Status (100 or more lifetime cigarettes plus current daily smoking)
Ability to read and speak English
Ability to provide written informed consent
Breath alcohol of 0.00 during informed consent
Provision of at least 1 EtG-positive urine test at any time during the induction period and at least one COT-positive urine test at any time during the induction period; and
Attended at least 4 of 6 possible visits during the induction period.

Exclusion Criteria5

Significant risk of dangerous alcohol withdrawal, defined as a history of alcohol detoxification or seizure in the last 12 months and expression of concern by the participant about dangerous withdrawal
Currently receiving any pharmacotherapy for alcohol
Currently receiving any pharmacotherapy for smoking
No suicide attempt in the last 20 years and
Any other medical (discernable by initial blood tests) or psychiatric condition that Drs. Layton or Rodin determine would compromise safe participation.

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