RecruitingNot ApplicableNCT05192759

Effect of Theta-Burst Transcranial Magnetic Stimulation (TBS) for Freezing of Gait


Sponsor

Anhui Medical University

Enrollment

40 participants

Start Date

Nov 22, 2021

Study Type

INTERVENTIONAL

Conditions

Summary

To investigate the treatment effect of Theta-burst Transcranial Magnetic Stimulation (TBS) on patients with freezing of gait (FOG) and the underlying neural mechanism.


Eligibility

Min Age: 40 YearsMax Age: 85 Years

Inclusion Criteria4

  • diagnosis of FOG with expertise in movement disorders.
  • the score of item 3 of the FOG questionnaire ≥1.
  • ongoing treatment with a stable dose of any medication for 2 months.
  • years of age or older.

Exclusion Criteria7

  • a history of addiction, psychiatric disorders, or neurological diseases other than PD.
  • focal brain lesions on T1-/T2-weighted fluid-attenuated inversion recovery images.
  • anti-PD medication adjustments during rTMS treatment.
  • history of substance abuse within the past 6 months.
  • nonremovable metal objects in or around the head.
  • previously received rTMS treatment.
  • prior history of seizure or history in first-degree relatives.

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Interventions

DEVICETranscranial Magnetic Stimulation

The stimulations were performed by MagStim Rapid2.


Locations(1)

Cognitive Neuropsychology Lab Anhui Medical University

Hefei, Anhui, China

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NCT05192759


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