RecruitingPhase 1Phase 2NCT05199311

Carfilzomib, Iberdomide (CC-220) and Dexamethasone (KID) in Transplant Eligible Multiple Myeloma

A Phase I/II Study of Carfilzomib, Iberdomide (CC-220) and Dexamethasone (KID) in Patients With Newly Diagnosed Transplant Eligible Multiple Myeloma


Sponsor

Hackensack Meridian Health

Enrollment

66 participants

Start Date

May 13, 2022

Study Type

INTERVENTIONAL

Conditions

Summary

This is a multi-institution, open label, phase I/II study of Iberdomide, Carfilzomib, and dexamethasone (KID) in patients with newly diagnosed transplant eligible MM.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a combination of three drugs — carfilzomib, iberdomide, and dexamethasone — as an initial treatment for newly diagnosed multiple myeloma in patients who are candidates for a stem cell transplant. **You may be eligible if...** - You are 18 or older - You have been newly diagnosed with multiple myeloma - You are healthy enough to undergo a stem cell transplant - You have had no more than 1 cycle of prior treatment for myeloma - Your organ function (kidney, liver, heart, blood counts) meets required levels **You may NOT be eligible if...** - You have had more than 1 prior cycle of myeloma treatment - You are not a candidate for stem cell transplant - You have serious heart, kidney, or liver problems - You have active infections or uncontrolled other cancers Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGCarfilzomib

20 mg/m2 C1D1; 56 mg/m2 thereafter

DRUGIberdomide

Oral CC-220 at dose specified by cohort dose level from Day 1-21 of each 28-day cycle

DRUGOral Dexamethasone

40 mg (\<=75 years old); 20 mg (\>75 years old)


Locations(2)

Lombardi Comprehensive Cancer Center

Washington D.C., District of Columbia, United States

John Theurer Cancer Center

Hackensack, New Jersey, United States

View Full Details on ClinicalTrials.gov

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NCT05199311


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