RecruitingNot ApplicableNCT05206305

Sensory-Evoked Cortical Gamma Oscillation

Sensory-Evoked Cortical Gamma Oscillation: Impact on Visual Processing and Cognitive Function in Patients With Alzheimer's Disease

Sponsor

University of Tennessee Medical Center

Enrollment

20 participants

Start Date

Jul 1, 2022

Study Type

INTERVENTIONAL

Conditions

Alzheimer Disease

Summary

The purpose of the study is to investigate the efficacy of cortical gamma oscillation on visual sensory processing and cognitive function in Alzheimer's Disease (AD) patients by combining a therapeutic sensory stimulation device capable of evoking 40-Hz gamma oscillation via non-invasive visual and auditory stimulation with pre-established markers of cortical network activity, i.e., electroencephalography (EEG) and event-related potentials (ERP), to evaluate the applicability of the 40-Hz multimodel sensory stimulation as a novel therapeutic approach for treatment of AD patients.

Eligibility

Min Age: 60 Years

Inclusion Criteria4

Individuals ages 60 and older with established diagnosis of Alzheimer's Disease as defined by the current consensus criteria for AD (Albert et al, 2011, Jack et al, 2011; McKhann et al, 2011)
Fluent and literate in English language
Able to consent for themselves based upon the MacArthur Competence Assessment Tool for Clinical Research
Patients with a pre-existing positive A(beta)-PET and/or CSF tau/A(beta) markers or willingness to undergo a Lumbar Puncture (LP) with these results

Exclusion Criteria6

Not fluent and literate in English
Severe dementia
Other medical conditions/neurodegenerative disease that could significantly impair cognitive abilities
Cardiac pacemakers or any other implants that may not be compatible with MRI
Cognitively impaired to the point the patient is unable to consent for themselves
Claustrophobic to the point that medication is required

Interventions

DEVICEGammaSense Stimulation device

Cognito Therapeutics GammaSense Stimulation device delivers sensory (auditory and visual) stimuli at a rate of 40 Hz to the wearer for one hour each day.