NextGen - Clinical Implication of Next Generation Sequencing
Clinical Implication of Next Generation Sequencing of Urinary Bacteria in Patients With Low Colony Forming Units of Bacteria in Traditional Urine Culture
Wake Forest University Health Sciences
100 participants
May 17, 2022
INTERVENTIONAL
Conditions
Summary
Recently more advanced techniques, including Polymerase Chain Reaction (PCR) and Next Generation Sequencing (NGS) are available to detect bacteria in urine based on bacterial genomes. Comparing to traditional culture, these techniques have more sensitivity and could potentially be of a great help in patients with Colony Count of less than 10,000 and more than zero.
Eligibility
Inclusion Criteria4
- Female at least 18 years of age
- U/C (Urinary Culture) growth of \<10,000 Colony-Forming Units (CFU)
- Understanding and acceptance of the need to return for all scheduled follow-up visits
- Able to give informed consent
Exclusion Criteria5
- Catheter in use (Foley or suprapubic or intermittent)
- Not able to provide clean midstream urine
- Antibiotic consumption in the past 2 weeks before signing the consent
- Pregnant or Planning to Conceive
- Incarcerated
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Interventions
FDA approved and marketed antibiotic treatment for the patients with UTI symptoms and CC \>0 and \<10,000
Next Generation Sequencing (NGS) is available to detect bacteria in urine based on bacterial genomes.
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT05206500