Comparisons of Metabolic Effect of Sleeve Gastrectomy With Duodenojejunal Bypass and Sleeve Gastrectomy (MEDUSA): A Multicenter Randomized Controlled Trial

This study is comparing two types of weight-loss surgery for people with type 2 diabetes and obesity: standard sleeve gastrectomy (stomach reduction) versus sleeve gastrectomy combined with a small intestinal bypass. The goal is to find which surgery better controls blood sugar and potentially puts diabetes into remission. **You may be eligible if...** - You are over 18 years old - Your BMI is 27.5 kg/m² or higher - You have had type 2 diabetes for 10 years or less - You are using insulin, or your HbA1c (average blood sugar) is 7.0% or higher despite medication - You still produce some insulin (C-peptide level above 1.0 ng/mL) - You agree not to become pregnant for at least one year after surgery **You may NOT be eligible if...** - You have severe, uncontrolled acid reflux disease - You have had previous stomach or anti-reflux surgery - You have poorly controlled psychiatric illness requiring 3 or more psychiatric medications - You have attempted suicide in the past 12 months or have active substance abuse issues Talk to your doctor to see if this trial is right for you.