Effectiveness of Cryotherapy on the Fatigue of Patients With Multiple Sclerosis

This study is testing whole-body cryotherapy — brief exposure to extremely cold temperatures in a special chamber — for reducing fatigue in people with multiple sclerosis (MS). Fatigue is one of the most debilitating symptoms of MS, and this study explores whether cold therapy can help manage it. **You may be eligible if...** - You are between 18 and 65 years old - You have been diagnosed with multiple sclerosis - Your MS disability level is mild to moderate (EDSS score of 0–6) - Your MS has been in remission for at least 6 months (no relapse) - You are able to understand and follow the study protocol **You may NOT be eligible if...** - You are pregnant - You have a medical condition that makes cryotherapy unsafe for you - Your MS medications have significantly changed in the month before the study - You are unable to complete the full program Talk to your doctor to see if this trial is right for you.