SRS Compared With FSRS for Treatment of Intact Metastatic Brain Disease, FRACTIONATE Trial

This trial is comparing two types of focused brain radiation for cancer that has spread to the brain: standard single-session radiosurgery (SRS) versus a divided multi-session approach (FSRS). The goal is to see which method better controls tumors while reducing side effects. **You may be eligible if...** - You are 18 or older - You have one or more brain metastases (cancer that has spread to the brain from elsewhere in the body, such as lung or breast cancer) - At least one tumor is between 5 mm and 4 cm in size and has not been previously treated with radiation - You are well enough to undergo the procedure **You may NOT be eligible if...** - You have more than a certain number of brain tumors (limits apply) - Your brain tumor(s) have already been treated with brain radiation - You have certain types of tumors not suitable for radiosurgery (e.g., some lymphomas or small cell cancers) - You are pregnant Talk to your doctor to see if this trial is right for you.