RecruitingNot ApplicableNCT05227547

Mapping and Characterization of Alveolar Cells During Smoking and Chronic Obstructive Disease


Sponsor

Centre Hospitalier Intercommunal Creteil

Enrollment

186 participants

Start Date

Oct 5, 2022

Study Type

INTERVENTIONAL

Conditions

Summary

To evaluate the regenerative capacities of mesenchymal cells composing the microenvironment of alveolar type 2 cells in a population of patients, undergoing thoracic surgery for suspected cancer, who are smokers with and without COPD compared to non-smokers patients


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is mapping and characterizing the cells found in the lung's air sacs (alveoli) in people with and without smoking history and COPD. Researchers are collecting tissue during planned lung surgery to better understand how smoking and COPD change the cells at the molecular level. **You may be eligible if...** - You are 18 or older - You are already scheduled to have lung resection surgery (lobectomy, pneumonectomy, or segmentectomy) for cancer or suspected cancer - You are affiliated with a French social security plan **You may NOT be eligible if...** - You have a chronic autoimmune disease - You received chemotherapy before your surgery - You have had prior chest radiation therapy - You are under legal guardianship Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERThoracic resection surgery

Patients undergoing thoracic resection surgery (pneumonectomy, lobectomy, segmentectomy) for cancer or suspected cancer, including smokers (active or ex-smokers) and non-smokers, with COPD and without COPD, and non-smoking patients.


Locations(4)

Rousseau-Bussac

Créteil, France

Hopital Cochin

Paris, France

HEGP

Paris, France

Hopital Tenon

Paris, France

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NCT05227547


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