RecruitingNot ApplicableNCT05230784

The PURI-HF (Air Purifiers on Heart Failure) Trial

Effectiveness of Indoor Air Purifiers on Heart Failure Outcomes

Sponsor

NYU Langone Health

Enrollment

255 participants

Start Date

Mar 6, 2024

Study Type

INTERVENTIONAL

Conditions

Heart Failure

Summary

Indoor air pollution and fine mode particulate matter with an aerodynamic diameter smaller than 2.5 micrometers (PM2.5) is a major contributor to global morbidity and mortality, particularly due to cardiovascular disease. This project aims to demonstrate the efficacy, feasibility and effectiveness of portable air filters in improving indoor PM2.5 levels and improving functional capacity of heart failure patients with reduced ejection fraction in India. The findings from the project will add to existing knowledge of innovative and scalable strategies to improve environmental and cardiovascular health worldwide. The overall objective of this study is to demonstrate the efficacy, feasibility, and effectiveness of portable air filters in improving indoor PM2.5 levels and improving functional capacity of heart failure patients with reduced ejection fraction in India.

Eligibility

Min Age: 18 Years

Inclusion Criteria1

Adults ≥ 18 years of age diagnosed with HF with a reduced ejection fraction of ≤ 40% within the last six months in NYHA class II-IV.

Exclusion Criteria5

listed for a cardiac transplant
history of CRT device implantation in last 3 months
on oxygen therapy
with severe pulmonary disease
participants unable to ambulate

Interventions

OTHERAirOk Air Purifier

The AirOk purifier nests on a locally developed patented technology that combines HEPA (grade H12) and a novel EGAPA (Effective Granular Adsorbent Particulate Arrestor) to reduce indoor air pollution. The HEPA filter removes all particulate matter up to 0.3 µm in aerodynamic diameter, and the dual stratified EGAPA filter removes other pollutants such as sulfur, nitrous oxide, carbon oxide, volatile organic compounds, allergens, and mold.

OTHERPlacebo Air Filter

Participants in the placebo arm will receive an air purifier with only the EGAPA filter.