RecruitingNCT07083557

Routine Validation and Reproducibility Testing of Laboratory Assays and Research Techniques Used for Endocrine, Cardiometabolic, and Musculoskeletal Disorder Research (VALD)


Sponsor

Bettina Mittendorfer

Enrollment

100 participants

Start Date

Jan 1, 2026

Study Type

OBSERVATIONAL

Conditions

Summary

The purpose of this research study is to validate (check the accuracy of) laboratory assays, intravenous catheter insertion, and equipment or devices and their reproducibility, which is necessary to perform high quality research on chronic diseases, nutrition, and metabolism (the process by which a substance is handled in the body) at the University of Missouri. As technology changes and uses new testing methods, it is necessary to compare results from old tests, equipment and devices and new tests, equipment, or devices and the reproducibility of these measurements to make sure the results are accurate. Reproducibility means performing the same test more than once to see if the same results can be achieved each time. This study will look at the validation and reproducibility of tests and laboratory assays in participants who are healthy or affected by relevant endocrine, cardiometabolic, and musculoskeletal disorders.


Eligibility

Min Age: 18 YearsMax Age: 100 Years

Plain Language Summary

Simplified for easier understanding

This study is testing and validating various laboratory methods used in research on hormone, heart, metabolic, and bone or muscle disorders. It is not testing a treatment — researchers are checking that their scientific tools and tests produce accurate and repeatable results. **You may be eligible if...** - You are between 18 and 100 years old - Your BMI is between 16.0 and 60 kg/m2 - You have no severe dietary restrictions (not vegan or vegetarian) - You do not exercise more than 150 minutes per week in structured exercise (unless that is what is being studied) **You may NOT be eligible if...** - You have allergies or intolerances to common meal ingredients - You take medications that could interfere with the specific test being evaluated - You have significant organ disease not relevant to what is being tested - You have an alcohol use disorder Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHEREndothelial cell collection

Participants may opt to have testing performed including blood sampling, urine sampling, intravenous catheter placement with endothelial cell collection, oral glucose tolerance test, consuming a test meal, having imaging performed such as MRI, DEXA, MRS, having adipose (fat) or muscle biopsies, or non-invasive endothelial function testing to investigate use of different assays, different sample treatment approaches to determine optimal conditions that produce the most accurate and reproducible results, and/or repeat testing on different days or with different equipment that measures the same variable.


Locations(1)

University of Missouri-Columbia

Columbia, Missouri, United States

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NCT07083557


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