RecruitingNCT05232240

Blood Pressure Variability in Non-hypertensive Patients With Ischemic Cerebrovascular Disease

Sponsor

Xuanwu Hospital, Beijing

Enrollment

300 participants

Start Date

Feb 14, 2022

Study Type

OBSERVATIONAL

Conditions

Blood Pressure Variability Ischemic Cerebrovascular Disease

Summary

This study is a single-center prospective cohort of patients with ischemic cerebrovascular disease (ICVD) who have not met the diagnostic criteria for hypertension. Ambulatory 24-hour blood pressure monitoring (ABPM) will be performed at baseline and one year after the enrollment. The primary purpose of the study is to delineate the relationship of blood pressure variability (BPV) with the risk of composite vascular events in non-hypertensive patients with ICVD. The factors related to BPV, as well as the potential modulators of the associations between BPV and vascular risk, will be further explored among these patients.

Eligibility

Min Age: 18 Years

Inclusion Criteria4

Diagnosed as ischemic stroke or transient ischemic attack (TIA), with confirmation of computed tomography or magnetic resonance imaging.
Less than 90 days after onset of ischemic stroke or TIA symptoms.
The blood pressure measured 5~90 days after the ICVD onset without any anti-hypertension treatment is less than 140/90 mmHg (an average of ≥2 readings obtained on ≥ 2 occasions after emptying bladder, relaxing for more than 5 min, and avoiding caffeine, exercise, or smoking for at least 30 min before measurement).
Consent to participate in the study.

Exclusion Criteria10

A definite diagnosis of hypertension.
Under anti-hypertension treatment.
Worsening neurological conditions.
With a National Institute of Health Stroke Scale score more than 5 points.
Intracranial hemorrhage.
Autonomic failure.
With malignant tumors or poor organ functions or hematologic diseases, whose estimated life expectancy is less than 3 years.
With contraindications to ambulatory 24-hour blood pressure monitoring or fail to finish the examination at baseline.
Mental disease.
Pregnant.

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Interventions

DIAGNOSTIC_TESTblood pressure variability measured by ambulatory 24-hour blood pressure monitoring

The ambulatory 24-hour blood pressure monitoring will be performed at baseline and one year after the enrollment. Various blood pressure variability characteristics will be obtained from these examinations.