Height Adjusted Versus Standardized Dose of Bupivacaine for Spinal Anesthesia
Height Adjusted Versus Standardized Dose of Bupivacaine in Spinal Anesthesia for Caesarean Delivery - A Randomized Double-blind Interventional Study
University Hospital, Caen
250 participants
Feb 23, 2022
INTERVENTIONAL
Conditions
Summary
General anesthesia during pregnancy is associated with several major risks including unanticipated difficult airway, pulmonary aspiration, and specific anesthetic effects on the newborn. Thus, intrathecal anesthesia is the technique of choice for cesarean section. Nevertheless, the main side effect of intrathecal anesthesia is arterial hypotension which depend mainly on the dose of local anesthetic administered intrathecally. To date there is no guidelines nor evidences whic help the anesthetist to precisely estimate the required dose. Most often a "standardized dose" of 8 to 10 mg of bupivacaine is administered. However, some data suggest that a lower dose may be administered resulting in less frequent arterial hypotension. Nevertheless, a well designed randomized study is lacking.
Eligibility
Inclusion Criteria3
- scheduled cesarean section with intrathecal anesthesia
- term pregnancy \> 35 weeks
- signed informed consent
Exclusion Criteria5
- unscheduled or emergent cesarean section
- any contra indication to intrathecal anesthesia
- any antihypertensive drug prescribed to control arterial pressure during pregnancy
- pre-eclampsia and eclampsia
- history of Marfan or Ehlers Danlos disease
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Interventions
intrathecal anesthesia with 10 mg of bupivacaine
intrathecal anesthesia with 0.05 mg of bupivacaine par cm of patient's height
Locations(1)
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NCT05233462