RecruitingNot ApplicableNCT05236153

Electroanatomic Interactions Between Transcatheter Pulmonary Valve Prostheses and Anatomic Isthmuses in Repaired Tetralogy of Fallot


Sponsor

Boston Children's Hospital

Enrollment

60 participants

Start Date

Nov 4, 2022

Study Type

INTERVENTIONAL

Conditions

Summary

Individuals with repaired Tetralogy of Fallot (rTOF) remain at risk for sudden cardiac death from ventricular tachycardia (VT). Transcatheter pulmonary valve replacement (TPVR) indications continue to broaden, yet its capability to reduce the risk of VT and sudden cardiac death remains unknown. Thus, in a cohort of participants with rTOF who are presenting for TPVR the investigators intend to: (1) quantify and localize right ventricular (RV) isthmuses with abnormal voltage and/or conduction velocity; (2) identify which RV isthmuses are at risk of being "jailed" by TPV prostheses; and (3) explore the feasibility of omnipolar technology to characterize wavefront directionality and differentiate slow conduction from conduction block.


Eligibility

Inclusion Criteria3

  • Diagnosis of tetralogy of Fallot (TOF) or double outlet right ventricle (DORV)
  • Referred for transcatheter pulmonary valve replacement (TPVR) per routine clinical indications
  • Weight >=25 kg

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Interventions

DIAGNOSTIC_TESTElectroanatomic substrate mapping

Participants will undergo a sinus rhythm RV substrate map using the HD Grid catheter (Abbott) and the Ensite X electroanatomic mapping system (Abbott) prior to TPVR.


Locations(1)

Boston Children's Hospital

Boston, Massachusetts, United States

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NCT05236153


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