RecruitingNCT05242393

The Role of Circadian Factors in Regulation of Neuroplasticity in Ischemic Stroke (Observational)

Sponsor

Federal State Budgetary Institution, V. A. Almazov Federal North-West Medical Research Centre, of the Ministry of Health

Enrollment

250 participants

Start Date

May 1, 2018

Study Type

OBSERVATIONAL

Conditions

Stroke, Ischemic Sleep Disorder

Summary

The study is aimed at the investigation of the association of biomarkers of circadian rhythms with sleep characteristics and stroke outcome in acute stroke patients. It is designed as an observational cohort study with the retrospective and prospective longitudinal arms.

Eligibility

Min Age: 18 YearsMax Age: 80 Years

Inclusion Criteria6

acute (symptom onset to admission <1 days) ischemic stroke
ischemic stroke affecting the branches of anterior cerebral artery, middle cerebral artery and posterior cerebral artery
age 18-80 years
moderate or severe stroke (National Institutes of Health Stroke Scale, NIHSS>=5)
intravascular stroke treatment with thrombolysis or thrombectomy leading to satisfactory reperfusion (if applicable)
informed consent

Exclusion Criteria9

secondary parenchymal hemorrhage (>hemorrhage index -2)
clinically unstable or life-threatening conditions
known progressive neurological diseases
known psychiatric diseases
concomitant benzodiazepine medication
drug or alcohol abuse
pregnancy
disability to participate in the study
congestive heart failure with reduced ejection fraction (<=45%) or New York Heart Association (NYHA) classification III-IV functional class