RecruitingNCT05250349

TRAnscranial Doppler CErebral Blood Flow and Cognitive IMPAIRment in Heart Failure

TRAnscranial Doppler CErebral Blood Flow and Cognitive IMPAIRment in Patients With Heart Failure and Presence/Absence of Atherosclerotic Carotid Artery Stenosis

Sponsor

John Paul II Hospital, Krakow

Enrollment

300 participants

Start Date

Sep 1, 2021

Study Type

OBSERVATIONAL

Conditions

Heart Failure Cognitive Impairment Carotid Stenosis

Summary

TRACE-IMPAIR is a prospective, clinical study of consecutive patients that evaluates the relationship between heart failure (HF) and cognitive impairment in relation to carotid and cerebral flow. The carotid and cerebral flow will be assessed using Doppler ultrasonography, and cognitive function will be estimated during routine neuropsychological tests. It is an observational, three(natural)-group, single-center study. It is also an Academic Registry - the scientific activity of the Faculty of Medicine, Collegium Medicum, Jagiellonian University, and John Paul II Hospital.

Eligibility

Min Age: 18 Years

Inclusion Criteria3

Clinically stable patients (NYHA I-III symptoms) with HF (for at least 6 months) either of ischemic or inflammatory etiology as well as genetic cardiomyopathies
Signed informed consent form
Consent to imaging studies: echocardiography, carotid and transcranial Doppler sonography and neuropsychological tests (MMSE and MoCA).

Exclusion Criteria11

Co-existing, severe, irreversible disease (e.g. advanced cancer)
Previously diagnosed dementia (including severe dementia - MMSE and MoCA score \<10)
Psychiatric condition which may influence cognitive function
Acute, decompensated HF
Reversible cause of HF - tachyarrhytmic, peripartum or toxic cardiomyopathy, acute myocarditis, acute myocardial infarction
Aortic stenosis
Cerebral stroke in the preceding 3 months
Lack of transcranial Doppler acoustic window
Echocardiographic projections precluding adequate measurements
Anemia with Hemoglobin \< 8 g/dl
Alcohol or psychoactive agents abuse