Cognitive Impairment Clinical Trials

163 recruiting

Cognitive Impairment Trials at a Glance

437 actively recruiting trials for cognitive impairment are listed on ClinicalTrialsFinder across 6 cities in 46 countries. The largest study group is Not Applicable with 249 trials, with the heaviest enrollment activity in Toronto, New York, and Boston. Lead sponsors running cognitive impairment studies include The University of Hong Kong, Johns Hopkins University, and Riphah International University.

Browse cognitive impairment trials by phase

Treatments under study

About Cognitive Impairment Clinical Trials

Looking for clinical trials for Cognitive Impairment? There are currently 163 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Cognitive Impairment trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Cognitive Impairment clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 437 trials

Recruiting
Phase 1

PET Imaging of Phosphodiesterase-4 (PDE4) in Volunteers With Alzheimer Disease (AD) or Mild Cognitive Impairment (MCI)

HealthyMild Cognitive ImpairmentAlzheimer s Disease
National Institute of Mental Health (NIMH)90 enrolled1 locationNCT07169630
Recruiting
Not Applicable

Closed-Loop Brain Stimulation as a Potential Intervention for Cognitive Decline

Mild Cognitive Impairment
University of Texas at Austin180 enrolled1 locationNCT05907343
Recruiting
Not Applicable

Personalized Digital Training for COGnitive FITness in Mild Cognitive Impairment

Mild Cognitive Impairment (MCI)Subjective Cognitive Decline (SCD)
Giovanna Zamboni100 enrolled2 locationsNCT07286448
Recruiting
Not Applicable

Feasibility of Web-based Therapy Sessions

Cognitive ImpairmentAcquired Brain InjurySpeech Dysfunction
Liverpool University Hospitals NHS Foundation Trust80 enrolled1 locationNCT07560696
Recruiting
Not Applicable

Non-invasive Stimulation of Deep Brain Structures to Modulate Working Memory

Mild Cognitive Impairment (MCI)Older Adults (60 - 85 Years Old)
Masaryk University70 enrolled1 locationNCT07560904
Recruiting
Not Applicable

Characterizing Variability in Hearing Aid Outcomes in Among Older Adults With Alzheimer's Dementia

Dementia of Alzheimer TypeHearing Loss, SensorineuralAmnestic Mild Cognitive Impairment
Northwestern University20 enrolled2 locationsNCT04240561
Recruiting
Not Applicable

tDCS on Parkinson's Disease Cognition

Parkinson DiseaseMild Cognitive Impairment
University of Manitoba36 enrolled1 locationNCT03025334
Recruiting
Not Applicable

Dance Intervention to Improve Executive Function and Physical Performance in Older Adults With Cognitive Impairment

Older AdultsCognitive Impairment, Mild
Taipei Medical University Shuang Ho Hospital50 enrolled1 locationNCT07105800
Recruiting
Phase 3

Effect of Metformin on Behaviour and the Brain in Children Treated for a Brain Tumour

Cognitive ImpairmentMedulloblastoma, Childhood
Donald Mabbott140 enrolled20 locationsNCT05230758
Recruiting

Identifying Cerebral Hemodynamic Patterns in Mood Disorders and Mild Cognitive Impairment: A Functional Near-Infrared Spectroscopy (fNIRS) Study

Major Depressive DisorderBipolar DisorderMild Cognitive Impairment
Mayo Clinic200 enrolled1 locationNCT06897670
Recruiting
Not Applicable

Auditory Sleep Stimulation or Sham in People With Parkinson Disease Mild Cognitive Impairment During Cognitive Training

Mild Cognitive ImpairmentParkinson's Disease
University of Zurich50 enrolled1 locationNCT07441915
Recruiting

Genetic Studies of Early-onset Dementia

Mild Cognitive Impairment (MCI)Alzheimer Dementia (AD)Memory Loss+1 more
Columbia University1,000 enrolled1 locationNCT04906863
Recruiting

Investigating Dynamic Interactions in Distributed Cognitive Control Networks

Cognitive ImpairmentDementiaDepression+1 more
University of Alabama at Birmingham30 enrolled1 locationNCT05927974
Recruiting
Not Applicable

IHT for Mild Cognitive Impairment

Mild Cognitive ImpairmentMemory Impairment
University of North Texas Health Science Center66 enrolled1 locationNCT05495087
Recruiting
Not Applicable

Cognitive Training for Cancer Related Cognitive Impairment in Breast Cancer Survivors

Breast CancerCognitive Impairments
NRG Oncology386 enrolled680 locationsNCT05896189
Recruiting
Phase 1

Methylphenidate to Address Attention and Executive Deficits Among Children With Sickle Cell Disease

Cognitive ImpairmentSickle Cell DiseaseExecutive Dysfunction
St. Jude Children's Research Hospital72 enrolled1 locationNCT07226219
Recruiting
Not Applicable

A Multifocal tDCS-EEG Protocol for Improving Symptoms of Mild Cognitive Impairment and Early Dementia

DementiaAlzheimer DiseaseAlzheimer Disease, Early Onset+1 more
University of Campania Luigi Vanvitelli50 enrolled1 locationNCT06668610
Recruiting
Phase 1Phase 2

rTMS to Improve Cognition in Parkinson's

Mild Cognitive ImpairmentParkinson's Disease
VA Office of Research and Development56 enrolled2 locationsNCT03836950
Recruiting

CSF Protein Markers as Prognostic Indicators of the Response to CSF Shunt in Normotensive Hydrocephalus

Beta-amiloid and Phospho-tau Proteins in CSFVentricular Size After CSF ShuntCognitive Impairment and CSF Shunt+1 more
University of Valencia150 enrolled2 locationsNCT05915000
Recruiting
Not Applicable

Cognitive Training Intervention and Attitudes Towards Genetics

Cognitive ImpairmentHematologic NeoplasmsHematopoietic Cell Transplant
University of Alabama at Birmingham60 enrolled1 locationNCT03094026