Cognitive Impairment Clinical Trials

479 recruitingLast updated: June 17, 2026

There are 479 actively recruiting cognitive impairment clinical trials across 48 countries. Studies span Not Applicable, Phase 2, Phase 1, Phase 3, Early Phase 1, Phase 4. Top locations include New York, New York, United States, Toronto, Ontario, Canada, Baltimore, Maryland, United States. Updated daily from ClinicalTrials.gov.


Cognitive Impairment Trials at a Glance

479 actively recruiting trials for cognitive impairment are listed on ClinicalTrialsFinder across 6 cities in 48 countries. The largest study group is Not Applicable with 272 trials, with the heaviest enrollment activity in New York, Toronto, and Baltimore. Lead sponsors running cognitive impairment studies include Johns Hopkins University, Riphah International University, and The University of Hong Kong.

Browse cognitive impairment trials by phase

Treatments under study

About Cognitive Impairment Clinical Trials

Looking for clinical trials for Cognitive Impairment? There are currently 172 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Cognitive Impairment trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Cognitive Impairment clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 479 trials

Recruiting
Not Applicable

e-ALIGN: A Patient Portal-based Intervention to Align Medications With What Matters Most

DementiaMild Cognitive Impairment (MCI)Potentially Inappropriate Medication Use
Johns Hopkins University100 enrolled1 locationNCT07454824
Recruiting
Phase 1

PET Imaging of Phosphodiesterase-4 (PDE4) in Volunteers With Alzheimer Disease (AD) or Mild Cognitive Impairment (MCI)

HealthyMild Cognitive ImpairmentAlzheimer s Disease
National Institute of Mental Health (NIMH)90 enrolled1 locationNCT07169630
Recruiting
Phase 2

CBD for Individuals at Risk for Alzheimer's Disease

Mild Cognitive Impairment
University of Colorado, Denver236 enrolled1 locationNCT05822362
Recruiting
Not Applicable

Music for Pain and Dementia

DementiaCaregiverAlzheimer Disease+2 more
Yale University60 enrolled1 locationNCT07602283
Recruiting
Not Applicable

The Cognitive Protective Effect of VR-based Cognitive Training in Type 2 Diabetes Patients With Mild Cognitive Impairment

Type 2 Diabetes Mellitus (T2DM)Mild Cognitive Impairment (MCI)
The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School40 enrolled1 locationNCT07650318
Recruiting
Not Applicable

Using Light Therapy for Mild Cognitive Impairment

Mild Cognitive Impairment (MCI)Amyloid Pathology
University of Oklahoma40 enrolled1 locationNCT07651787
Recruiting
Not Applicable

Temporal Interference Stimulation Treatment in Patients With Cognitive Impairment

FTDAD - Alzheimer's DiseaseAD-MCI+1 more
Tianjin Huanhu Hospital60 enrolled1 locationNCT07643363
Recruiting
Phase 2

Biomarker-based Trial of NPC-1 for Alzheimer's Pathology

Alzheimer DiseaseMild Cognitive Impairment (MCI)Subjective Cognitive Decline (SCD)
Massachusetts General Hospital40 enrolled1 locationNCT07236190
Recruiting

InRAD Observational Study

Mild Cognitive Impairment (MCI)Alzheimer's Disease(AD)Subjective Cognitive Decline (SCD)+1 more
Stichting International Registry for Alzheimer's Disease and other Dementias Foundation50,000 enrolled2 locationsNCT07213700
Recruiting

Dementia With Lewy Bodies: Clinical Symptoms, Biomarkers and Progression

Mild Cognitive Impairment (MCI)Other DementiasCognitively Unimpaired+1 more
Karolinska Institutet600 enrolled1 locationNCT07629349
Recruiting

Assessment of Motor Reserve in the Preclinical Stages of Dementia

Mild Cognitive Impairment (MCI)
Istituto per la Ricerca e l'Innovazione Biomedica200 enrolled1 locationNCT07634055
Recruiting
Phase 4

Pragmatic Evaluation of Events And Benefits of Lipid-lowering in Older Adults

Cardiovascular DiseasesDementiaCognitive Impairment, Mild
Duke University20,000 enrolled103 locationsNCT04262206
Recruiting

Crownlands Observing Progression With Neurons Study

Mild Cognitive Impairment (MCI)Alzheimer s Disease
Crownlands160 enrolled1 locationNCT07611396
Recruiting
Phase 1

Safety And Tolerability Of Gamma Glutamylcysteine (GGC) Oral Supplementation In MCI Patients

Mild Cognitive Impairment (MCI)
Pravat Mandal9 enrolled1 locationNCT07583251
Recruiting
Not Applicable

Telehealth-Adapted Compensatory Training and Intervention for Cognition

Mild Cognitive Impairment (MCI)Mild Cognitive ImpairmentMCI
University of Florida100 enrolled1 locationNCT07366346
Recruiting
Not Applicable

Effect of Gerofit Exercise on Cognition in Older Veterans

Cognitive ImpairmentPhysical ActivityAging
VA Office of Research and Development150 enrolled2 locationsNCT06107842
Recruiting
Not Applicable

How Video Game Therapy Affects Thinking and Emotions in Older Adults With Cognitive Impairment

Older Adults (65 Years and Older)Cognitive Impairment, Mild
Golden Gamers Go SL60 enrolled1 locationNCT07615647
Recruiting
Not Applicable

Train Your Brain Fitness SC: An Exercise Intervention for People With Cognitive Impairments

Mild-moderate Cognitive Impairment
University of South Carolina50 enrolled2 locationsNCT06799429
Recruiting
Phase 2

Human Mesenchymal Stem Cells & Monoclonal Antibodies in the Treatment for Mild Cognitive Impairment or Early Alzheimer's Disease.

Mild Cognitive ImpairmentEarly Alzheimer's DiseaseAD-MCI
Bernard (Barry) Baumel10 enrolled1 locationNCT07512362
Recruiting
Not Applicable

Effects of Transcutaneous Vagal Nerve Stimulation on Post-Surgical Return to Consciousness, Delirium, and Depression

Cognitive ImpairmentDepressionVagus Nerve Stimulation+1 more
Northwestern University40 enrolled1 locationNCT07610655