RecruitingNCT05250557

Prognostic Impact of Lesion-specific Hemodynamic Index in Patients With Coronary Artery Disease

Prognostic Impact of Lesion-specific Hemodynamic Index and Disease Characteristics in Patients With Coronary Artery Disease Assessed by Fractional Flow Reserve


Sponsor

Seoul National University Hospital

Enrollment

2,429 participants

Start Date

Aug 1, 2021

Study Type

OBSERVATIONAL

Conditions

Summary

The investigators aim to investigate the additive prognostic value of lesion-specific hemodynamic index such as ΔFFR, non-hyperemic pressure ratio such as RFR, over % diameter stenosis and FFR according to treatment strategy, and to find the prognostic implications of post-PCI FFR after adjustment of various clinical and disease characteristics, and to construct a comprehensive risk prediction model for post-PCI outcomes.


Eligibility

Min Age: 20 Years

Plain Language Summary

Simplified for easier understanding

This study is examining whether a detailed measurement of blood flow in specific blocked heart arteries — obtained during a cardiac catheterization procedure — can help predict long-term outcomes for patients with coronary artery disease. Researchers are looking at whether this index can improve decision-making about treatment. **You may be eligible if...** - You are 20 years or older - You have undergone a successful FFR (fractional flow reserve) measurement — a test done during cardiac catheterization to assess blood flow in coronary arteries **You may NOT be eligible if...** - You have severe chronic kidney disease (eGFR less than 30) - You had a heart attack within the last 72 hours - You have had prior bypass surgery - You have primary heart muscle disease or valve disease - Your heart pumping function is severely reduced (ejection fraction below 30%) - You are hemodynamically unstable - Your life expectancy is less than 2 years Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIAGNOSTIC_TESTFractional flow reserve

Physiologic assessment includes Δ FFR (lesion-specific) and FFR (vessel-specific) measurement. Δ FFR is defined as a pressure step up across the lesion. Coronary angiography and physiologic assessment will be analyzed by an independent core laboratory (Seoul National University Hospital, Clinical Trial Center, Seoul, South Korea).


Locations(1)

Seoul National University Hospital

Seoul, South Korea

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NCT05250557


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