RecruitingNot ApplicableNCT05257967

CSF Analysis in EGFR Mutant Non-Small Cell Lung Cancer With Leptomeningeal Disease

CSF Liquid Biopsy Based Characterization of Leptomeningeal Disease in EGFR Mutant Non-Small Cell Lung Cancer

Sponsor

British Columbia Cancer Agency

Enrollment

10 participants

Start Date

Jul 18, 2022

Study Type

INTERVENTIONAL

Conditions

Leptomeningeal Metastasis EGFR Activating Mutation

Summary

Leptomeningeal disease is malignant seeding of the leptomeninges and presents with a variety of symptoms frequently impacting quality of life. With improvement in treatment options, rates of leptomeningeal disease are increasing and currently found in up to 9% of EGFR mutant NSCLC. Systemic therapy may be more effective if it can target the correct molecular aberration. The molecular characterization of central nervous system disease may differ from disease outside of the central nervous system. The aim of this pilot trial is to evaluate for molecular differences between cerebral spinal fluid (CSF) and blood circulating tumor DNA (ctDNA) through the use of ddPCR and BC Cancer NGS panel molecular testing.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is analyzing fluid from around the brain and spinal cord (called cerebrospinal fluid or CSF) in people with a specific type of lung cancer that has spread to the brain's outer lining (leptomeningeal disease). The goal is to better understand how the cancer spreads there and find markers that could guide treatment. **You may be eligible if...** - You are 18 years or older - You have been diagnosed with metastatic non-small cell lung cancer (NSCLC) with an EGFR mutation - Your cancer has spread to the brain's outer lining (confirmed by brain MRI or spinal fluid test) - You are well enough to undergo a lumbar puncture (spinal tap) **You may NOT be eligible if...** - You cannot safely have a lumbar puncture due to low platelet count or a bleeding disorder - You have cancer in your spinal cord's outer lining in a location that makes a lumbar puncture unsafe - Your treating doctor believes the procedure is otherwise too risky for you Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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