Interaction of Volatile Anesthetics With Magnesium
Interaction Between Intravenous Magnesium Sulfate and Volatile Anesthetics Compared to Propofol. A Three-center Prospective Randomized Single-blinded Electrophysiological Study
Christoph Czarnetzki
96 participants
Nov 18, 2022
INTERVENTIONAL
Conditions
Summary
Magnesium and volatiles anesthetics both have an effect on the neuromuscular transmission. The primary objective of the study is to quantify the effect of a perfusion of intravenous magnesium on neuromuscular transmission measured by electromyography device TetraGraph device in patients undergoing general anesthesia with volatile anesthetics (desflurane, sevoflurane and isoflurane) as compared to intravenous anesthesia with propofol.
Eligibility
Inclusion Criteria6
- Patients, age 18 to 65 years inclusive
- American Society of Anesthesiology \[ASA\] status I or II
- Body mass index 19 - 30 kg/m2
- Patient scheduled for elective surgery lasting ≥ 60 minutes
- Patient is able to read and understand the information sheet and to sign and date the consent form.
- Negative urinary or serum pregnancy test (not applicable if status post hysterectomy or tubal ligation or menopausal woman)
Exclusion Criteria13
- Surgery with need for neuromuscular block
- Contraindication for general anesthesia with laryngeal mask airway, such as gastro-oesophageal reflux.
- Hypersensitivity or allergy to magnesium sulfate or propofol
- Contraindication to volatile anesthetics such as malignant hyperthermia
- Patients with neuromuscular disease
- Patients receiving medications known to influence neuromuscular function (for instance, aminoglycosides or phenytoine)
- Known electrolyte abnormalities (for instance, hypermagnesemia)
- Atrioventricular heart block
- Patients with magnesium treatment within 48 hours before start of study
- Liver insufficiency (bilirubine <1.5x, ALAT/ASAT<2.5x the upper limit of normal value)
- Renal insuffisancy (créatinine <1.5x upper limit of normal value, clearance<30ml/minute)
- Patient having participated in any clinical trial within 30 days, inclusive, of signing the informed consent form of the current trial.
- Pregnant or breast-feeding women.
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Interventions
The experimental intervention is the injection of magnesium sulfate. This will be done as soon as TetraGraph calibration is done and neuromuscular measurements are stable. Each patient will receive 60 mg/kg of magnesium sulfate as an intravenous perfusion over 5 minutes. Vital signs before, during and after the perfusion will be taken and documented.
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT05261516