Haemoadsorption During Heart Transplantation
Effect of Haemoadsorption During Cardiopulmonary Bypass on Patients After Heart Transplantation
Medical University of Vienna
40 participants
Sep 1, 2022
INTERVENTIONAL
Conditions
Summary
To investigate whether the use of haemoadsorption (HA) on cardiopulmonary bypass during heart transplantation (HTX) has an effect on circulating cytokine levels for the first 120 hours after HTX and induces a decreased inflammatory response, increased anti-inflammatory response or immunosuppressive response. Additionally, the influence of HA on primary graft dysfunction, postoperative cerebral dysfunction, postoperative fluid accumulation, renal dysfunction, duration of mechanical ventilation, length of ICU-stay and 30-day mortality should be investigated
Eligibility
Inclusion Criteria1
- Adult patients undergoing heart transplantation
Exclusion Criteria6
- Declined informed consent
- Age < 18 years#
- Receiving antileukocyte drugs
- Receiving TNF-α Blockers, immunosuppressive drugs (e.g. tocilizumab)
- DCD
- Ex-vivo perfusion
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Interventions
Polymer based adsorber system for the elimination of cytokines
Locations(1)
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NCT05270902