Coronary Microvascular Dysfunction Assessments in Myocardial Infarction With Non-Obstructive Coronary Arteries
Clinical Relevance of Coronary Microvascular Dysfunction Assessments in Myocardial Infarction With Non-Obstructive Coronary Arteries
Chonnam National University Hospital
150 participants
Feb 14, 2022
OBSERVATIONAL
Conditions
Summary
To compare clinical outcomes of myocardial infarction with non-obstructive coronary arteries (MINOCA) according to the coronary microvascular dysfunction (CMD), evaluated by optical coherence tomography (OCT), invasive and non-invasive coronary physiologic assessment.
Eligibility
Inclusion Criteria6
- Subject with age ≥19 years and acute myocardial infarction
- Rise and/or fall of cardiac troponin with one level \>99 percentile plus ischemic signs/symptoms
- Subject with non-obstructive coronary arteries
- \<50% diameter stenosis or
- fractional flow reserve (FFR) \>0.80 ③ Subject without previous history of coronary artery disease
- Subject who performed invasive coronary angiography within 24 hours after presentation ⑤ Subject who eligible for invasive and non-invasive coronary physiologic assessment
Exclusion Criteria3
- Subject with obstructive coronary arteries
- Subject with alternate diagnosis including sepsis, pulmonary embolism, myocarditis, Takotsubo syndrome, spontaneous coronary dissection, and other cardiomyopathies.
- Subject with cardiogenic shock or cardiac arrest ④ Subject who has non-cardiac co-morbid conditions with life expectancy \<1 year ⑤ Subject or lactating women ⑥ Subject unable to provide consent
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Interventions
Intravascular imaging (OCT), Invasive physiologic assessment (FFR, CFR, IMR), or Non-invasive physiologic assessment (N-13 ammonia PET)
Locations(1)
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NCT05272618