RecruitingNCT05272618

Coronary Microvascular Dysfunction Assessments in Myocardial Infarction With Non-Obstructive Coronary Arteries

Clinical Relevance of Coronary Microvascular Dysfunction Assessments in Myocardial Infarction With Non-Obstructive Coronary Arteries


Sponsor

Chonnam National University Hospital

Enrollment

150 participants

Start Date

Feb 14, 2022

Study Type

OBSERVATIONAL

Conditions

Summary

To compare clinical outcomes of myocardial infarction with non-obstructive coronary arteries (MINOCA) according to the coronary microvascular dysfunction (CMD), evaluated by optical coherence tomography (OCT), invasive and non-invasive coronary physiologic assessment.


Eligibility

Min Age: 19 Years

Plain Language Summary

Simplified for easier understanding

This study examines why some people have a heart attack even though their coronary arteries are not significantly blocked — a condition called MINOCA (Myocardial Infarction with Non-Obstructive Coronary Arteries). Researchers are assessing the function of tiny blood vessels in the heart (microvascular dysfunction) to better understand the cause. You may be eligible if: - You are 19 years or older - You have had an acute heart attack (confirmed by troponin levels and symptoms) - Your coronary arteries show less than 50% blockage, or your fractional flow reserve (FFR) is above 0.80 - You have no previous history of coronary artery disease - You underwent invasive coronary angiography within 24 hours of arrival You may NOT be eligible if: - Your coronary arteries are significantly blocked - Your condition is explained by another cause (sepsis, pulmonary embolism, myocarditis, Takotsubo syndrome, spontaneous coronary dissection) - You are in cardiogenic shock or cardiac arrest - You have serious non-cardiac conditions with a life expectancy under 1 year - You are pregnant or breastfeeding - You are unable to give consent Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIAGNOSTIC_TESTIntravascular imaging (OCT), Invasive physiologic assessment (FFR, CFR, IMR), or Non-invasive physiologic assessment (N-13 ammonia PET)

Intravascular imaging (OCT), Invasive physiologic assessment (FFR, CFR, IMR), or Non-invasive physiologic assessment (N-13 ammonia PET)


Locations(1)

Chonnam National University Hospital

Gwangju, Gwangju, South Korea

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NCT05272618


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