RecruitingNCT05277025

Pain Processing in Inflammatory and Non-Inflammatory Chronic Pain Syndromes

Sponsor

University of Florida

Enrollment

150 participants

Start Date

Mar 22, 2022

Study Type

OBSERVATIONAL

Conditions

Rheumatoid Arthritis Fibromyalgia

Summary

Fibromyalgia (FM) is a chronic musculoskeletal pain disorder that afflicts up to 4% of the general population. The evaluation of pain mechanisms in FM has shown predominant central abnormalities and therefore has been designated as nociplastic pain syndrome. Rheumatoid arthritis (RA) is characterized by polyarthritis and pain from inflamed tissues, consistent with nociceptive pain. FM and RA patients may utilize overlapping pain mechanisms resulting in nociceptive and nociplastic pain.

Eligibility

Min Age: 18 YearsMax Age: 70 Years

Plain Language Summary

Simplified for easier understanding

This study investigates how the brain and nervous system process pain differently in people with fibromyalgia (widespread pain without clear tissue damage), rheumatoid arthritis (joint inflammation), and healthy individuals. **You may be eligible if...** - You are 18–70 years old - You meet standard diagnostic criteria for fibromyalgia (FM) — both the 1990 and 2011 ACR criteria - OR you meet criteria for rheumatoid arthritis (RA) based on the 2010 ACR-EULAR classification - OR you are a healthy volunteer with no significant pain, fatigue, depression, or anxiety **You may NOT be eligible if...** - You have diabetes - You have cancer - You have advanced liver, kidney, or heart disease - You have neuropathic pain (nerve-related pain, such as from diabetes or nerve damage) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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