An Ascending Dose Study of PIT565 in Participants With Rheumatoid Arthritis

This study is testing a new drug called PIT565 in people with rheumatoid arthritis (RA), starting at low doses and increasing gradually, to evaluate safety and find the right dose. **You may be eligible if:** - You are between 18 and 75 years old - You have been diagnosed with rheumatoid arthritis for at least 12 weeks - You have been vaccinated against pneumococcus, flu, meningococcus, and COVID-19 - You have moderately active RA despite current treatment **You may NOT be eligible if:** - You have a serious heart condition such as unstable angina, recent heart attack, or significant heart rhythm problems - You have active or serious infections - You are pregnant or breastfeeding - You have severe liver or kidney disease - You have a history of certain cancers - You are currently taking biologics or certain immune-suppressing medications that would conflict with the study drug Talk to your doctor to see if this trial is right for you.