Mycobacterial Lung Diseases in Virginia: Sequencing and Clinical Determinants of Relapse and Outcome

Inclusion Criteria13

• All subjects:
• Race/ethnicity: any
• Subject has no history of active Tuberculosis in the last 2 years.
• NTM culture positive from respiratory specimen (sputum or bronchial lavage fluid)
• Subject must have an available sputum sample that was taken in the last 2 years. If a sample is not available, the subject must be willing and able to provide a sputum sample.
• Meets the following Infectious Diseases Society of America (IDSA) criteria for NTM lung disease:
• or more sputum (or 1 bronchoscopy/biopsy) cultures positive for "Mycobacterium Avium Complex" or "Mycobacterium abscessus) within the last 2 years.
• Nodules, cavities, and/or bronchiectasis on CT scan within the past 2 years
• If if the above data are not available, but a patient's Infectious Disease or Pulmonary physician has documented the diagnosis of NTM lung disease in their notes, this will suffice
• PK subjects:
• Newly diagnosed with NTM lung disease and beginning antibiotics for NTM within the last 3 months from enrollment.
• Prior diagnosis of NTM lung disease, and starting initial therapy within the last 3 months prior to enrollment.
• Consent to pharmacokinetic testing within one month of enrollment and at six months of therapy