HD-tDCS Combined With Circadian Rhythm Reconstruction and Micro Expression Changes on Consciousness Recovery in Patients With Chronic Disturbance of Consciousness
Effect and Mechanism of HD-tDCS Combined With Circadian Rhythm Remodeling on Consciousness Recovery in Patients With Chronic Disorder of Consciousness
First Affiliated Hospital of Zhejiang University
90 participants
Jul 1, 2021
INTERVENTIONAL
Conditions
Summary
The circadian rhythm characteristics of sleep cycle and neuroendocrine in patients with chronic disorder of consciousness show different degrees of disorder, and the relationship between this disorder and consciousness level is unclear.The researchers used HD-tDCS to treat patients with chronic disturbance of consciousness who intervened in circadian rhythm, and used a variety of methods such as EEG, fMRI, protein metabolism, ERP and micro-expression to explore the mechanism of improving the state of consciousness of HD-DCS and the relationship between circadian rhythm and patients' consciousness level
Eligibility
Inclusion Criteria5
- Patients with diagnosis of disorder of consciousness
- Stable vital signs
- Good coordination, less spontaneous activity
- No anti-epileptic and sedative drugs taken within prior 24 hours
- The family members volunteered and signed the informed consent
Exclusion Criteria4
- locked-in syndrome
- Diseases and factors that may affect the judgment of brain function, such as metabolic diseases, poisoning, shock, etc.
- There are contraindications to MRI scanning, such as the presence of metal implants in the body
- Contraindications treated by transcranial direct current stimulation
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Interventions
Participants assigned to the melatonin group were given a 3-mg fast-release oral dose of melatonin administered at approximately 21:00
Participants in this group were treated according to a protocol identical to those receiving active medication at approximately 21:00. For the sham tDCS groups, the same stimulation parameters were employed, except that the stimulator had a built-in placebo mode; when it was activated, two ramp fade-in/fade-out periods in the beginning and the end of sham stimulation mimicked the somatosensory artifact of real tDCS
Direct current was applied using a battery-driven constant-current stimulator through saline-soaked surface sponge electrodes (7cm×5cm) with the anode placed over the left DLPFC (F3 according to the 10-20 international EEG system) and the reference cathode placed over the right supraorbital region (Fp2). During real tDCS, the current was increased to 2 mA from the onset of stimulation and applied for 20 minutes
Locations(1)
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NCT05285124