RecruitingPhase 1Phase 2NCT05295433

An Extension Study to Evaluate the Long-Term Safety and Clinical Activity of mRNA-3705 in Participants Previously Enrolled in Other Clinical Studies of mRNA-3705

A Phase 1/2, Global, Open-Label, Extension Study to Evaluate the Long-Term Safety and Clinical Activity of mRNA-3705 in Participants Previously Enrolled in Other Clinical Studies of mRNA-3705


Sponsor

ModernaTX, Inc.

Enrollment

56 participants

Start Date

Mar 8, 2022

Study Type

INTERVENTIONAL

Conditions

Summary

The primary objective of this study is to evaluate the long-term safety and clinical activity of mRNA-3705 administered to participants with isolated methylmalonic acidemia (MMA) due to methylmalonyl-coenzyme A mutase (MUT) deficiency who have previously participated in other clinical studies of mRNA-3705.


Eligibility

Min Age: 1 Year

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called mRNA-3705 for people with methylmalonic acidemia. The study is currently recruiting participants at 12 locations. People eligible for this study include aged 1 Year and older.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGmRNA-3705

A sterile liquid for injection


Locations(12)

UCLA Medical Center

Los Angeles, California, United States

Lucile Packard Children's Hospital at Stanford

Palo Alto, California, United States

Altman Clinical and Translational Research Institution

San Diego, California, United States

Stollery Children's Hospital University of Alberta

Edmonton, Alberta, Canada

Hospital For Sick Children

Toronto, Ontario, Canada

Hôpital Necker - Enfants Malades APHP

Paris, France

Erasmus MC

Rotterdam, Netherlands

Universitair Medisch Centrum Utrecht

Utrecht, Netherlands

Hospital Universitario Cruces

Barakaldo, Vizcaya, Spain

Hospital Universitario 12 de Octubre

Madrid, Spain

Birmingham Children's Hospital NHS Foundation Trust

Birmingham, United Kingdom

Royal Manchester Childrens Hospital

Manchester, United Kingdom

View Full Details on ClinicalTrials.gov

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NCT05295433


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