RecruitingNCT05300997

Translational Immunodiagnostics in Stroke (TrImS)

Translational Immunodiagnostics in Suspected Stroke (TrImS): A Two-centre, Pragmatic, Prospective, Observational Study

Sponsor

The University of Hong Kong

Enrollment

650 participants

Start Date

May 1, 2022

Study Type

OBSERVATIONAL

Conditions

Atrial Fibrillation Acute Ischemic Stroke Cardioembolic Stroke Haemorrhagic Stroke Transient Ischemic Attacks Large-Artery Atherosclerosis (Embolus/Thrombosis)Small Vessel Disease Stroke of Other Determined Etiology Stroke of Undetermined Etiology Stroke of Anterior Cerebral Artery Stroke of Middle Cerebral Artery Stroke of Basilar Artery

Summary

In adult patients presenting to emergency departments within 24 hours of symptom onset with suspected acute stroke, we aim: 1. to identify early brain- and pathology-specific circulating, whole blood, plasma and serum panorOmic biomarkers that enable early acute stroke detection, diagnosis, dynamics, differentiation, monitoring, prediction and prognosis. 2. to identify early brain- and pathology-specific, panorOmic biomarkers in saliva that enable early acute stroke detection, diagnosis, dynamics, differentiation, monitoring, prediction and prognosis. 3. to derive biomarker platforms of models for early acute stroke detection, diagnosis, dynamics, differentiation, monitoring, prediction and prognosis 4. to validate these models in independent and external datasets

Eligibility

Min Age: 18 YearsMax Age: 100 Years

Plain Language Summary

Simplified for easier understanding

This study looks at blood and immune markers in patients with suspected stroke or TIA (mini-stroke) to better understand and diagnose these events. Blood samples taken early can reveal patterns that help doctors tell different types of stroke apart and predict outcomes. **You may be eligible if...** - You are 18 or older and are being assessed for a suspected stroke or TIA (mini-stroke) - Your symptoms began within the last 24 hours - You or a family member can give consent - OR you are a healthy family member or friend of a patient (control participant) **You may NOT be eligible if...** - You cannot give or have someone give consent on your behalf - You are outside the 24-hour symptom window Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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