RecruitingNCT05305092

Assessment of Brain Cognitive Impairment in Breast Cancer

Integrated PET/MRI Study of Cognitive Impairment in Premenopausal Breast Cancer Patients After Chemotherapy or Endocrine Therapy


Sponsor

Tang-Du Hospital

Enrollment

90 participants

Start Date

May 31, 2022

Study Type

OBSERVATIONAL

Conditions

Summary

To explore the cognitive impairment caused by chemotherapy and endocrine therapy in premenopausal breast cancer patients and to find biomarkers with early predictive effect on this cognitive impairment by using multimodal integrated PET/MRI technology combined with psychobehavioral technology.


Eligibility

Sex: FEMALE

Plain Language Summary

Simplified for easier understanding

This study examines whether breast cancer treatment (specifically chemotherapy) causes cognitive changes — sometimes called "chemo brain" — in premenopausal women with early-stage breast cancer. Brain function is tested before and after treatment to track any changes. **You may be eligible if...** - You are a premenopausal woman with early-stage (stage I–II) primary breast cancer - You have not yet started any treatment other than surgery - You are right-handed, in good physical condition (ECOG 0–1), and can complete questionnaires - You are willing to use contraception during the study if needed **You may NOT be eligible if...** - You have already started chemotherapy or other cancer treatment - You are postmenopausal - You are left-handed - You are unable to complete the study assessments Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICEPET/MRI, psychobehavioral tests and questionnaires, serum biomarkers and stool sample

Neuroimaging data were collected by integrated PET/MRI machine, and collected the psychobehavioral data, the serum and stool samples of participants.


Locations(1)

Tangdu Hospital

Xi'an, Shaanxi, China

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NCT05305092


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