Trazodone vs. Quetiapine for the Treatment of ICU Delirium

This study compares trazodone versus quetiapine for treating ICU delirium - confusion and agitation that can affect patients in the intensive care unit. The study looks at which medication works better at calming symptoms, improving sleep, and reducing dangerous behaviors in critically ill patients. You may be eligible if: - You are 18 or older - You have been admitted to the surgical ICU for more than 24 hours - You have been diagnosed with delirium (confirmed by CAM-ICU assessment) with disruptive symptoms requiring medication - You are receiving either trazodone or quetiapine for delirium You may NOT be eligible if: - You were admitted with an acute neurological condition (stroke, brain injury, brain tumor) - You are pregnant or breastfeeding - You have a history of dangerous heart rhythms (torsade de pointes, heart block) - You have dementia, Parkinson's disease, schizophrenia, or another psychotic disorder - You cannot speak or understand English - You are expected to die or be transferred out of the ICU within 24 hours - You have a prolonged QT interval on ECG or a seizure disorder - You recently had a heart attack (within 30 days) - You are in alcohol or substance withdrawal - You have liver disease or symptomatic low sodium Talk to your doctor to see if this trial is right for you.