RecruitingNot ApplicableNCT05312255

Non-chemotherapeutic Interventions for the Improvement of Quality of Life and Immune Function in Patients With Multiple Myeloma

Improving Host Factors in Patients With Monoclonal Gammopathies and Other Hematologic Disorders

Sponsor

Roswell Park Cancer Institute

Enrollment

175 participants

Start Date

Jun 28, 2022

Study Type

INTERVENTIONAL

Conditions

Plasma Cell Myeloma Recurrent Plasma Cell Myeloma Refractory Plasma Cell Myeloma Smoldering Plasma Cell Myeloma

Summary

This clinical trial investigates the effect of non-chemotherapeutic interventions in patients with multiple myeloma or MDS. Non-chemotherapeutic interventions such as physical activity and nutritional interventions (e.g., modifications in diet) have been shown to positively affect the immune system and improve overall quality of life. Another purpose of this study is for researchers to learn how the addition of a beta-blocker (propranolol) to the standard treatment regimen in patients with newly diagnosed multiple myeloma affects immune response and quality of life. A study from the Mayo Clinic looked at multiple myeloma patients who were on a beta-blocker while undergoing chemotherapy and found that the use of a beta-blocker resulted in improved patient survival outcomes. Non-chemotherapeutic treatment options may help decrease symptoms and improve quality of life for patients with multiple myeloma.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study tests non-chemotherapy approaches — such as exercise, nutrition, stress management, or other wellness interventions — to improve quality of life and immune function in people with multiple myeloma (a blood cancer) or a related condition called myelodysplastic syndrome (MDS, a bone marrow disorder). **You may be eligible if...** - You are 18 or older - You have a diagnosis of smoldering multiple myeloma, active multiple myeloma, plasma cell leukemia, or low-risk MDS that does not require blood transfusions - Your general health status meets the study's activity requirements (ECOG 0–2 depending on which module you enroll in) - You are able to understand and follow the study procedures **You may NOT be eligible if...** - You have serious health complications from your myeloma or MDS that would make participation unsafe - Your doctor determines you are not a good candidate due to comorbidities or treatment side effects Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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