Sitting Interruption and Whole-body Cardiovascular Health
Sitting Interruption and Whole-body Cardiovascular Health: Linking Physiological Responses to Risk Behaviors
University of North Carolina, Chapel Hill
56 participants
Aug 15, 2022
INTERVENTIONAL
Conditions
Summary
There is strong evidence for the association between sedentary behaviors and cardiovascular diseases such as coronary heart disease and stroke. However, the public currently has no clear guidance on how to limit or interrupt their sedentary behaviors. This study will identify and test the physiological effects of several sedentary behavior interruption strategies and explore the feasibility (i.e., likelihood of an individual performing the requested activities) of those strategies to inform the development of public policy surrounding sedentary behavior interruption. Long-term, the findings of this study will inform a large clinical trial that can test whether sedentary behavior reduction can decrease cardiovascular disease risk.
Eligibility
Inclusion Criteria5
- Aged between 30-60 years
- Insufficiently active: self-reported exercise \<90 minutes per week for the past 3 months
- Sedentary: self-reported sitting \>8 hours per day
- Self-reported ability to walk 4 blocks and climb 2 flights of stairs
- Possession of cellular phone able to receive text messages
Exclusion Criteria11
- Use of assisted-walking devices
- Comorbid condition that would limit the ability to reduce sedentary behavior (e.g., musculoskeletal condition, current chemotherapy)
- Plans for major surgery within next 3 months
- Recent history (\<1 year) of ischemic heart disease, chronic heart failure, stroke, or chronic kidney disease
- Recent (\< 1 year) or planned bariatric surgery
- Systolic blood pressure ≥160 mmHg or diastolic blood pressure ≥100 mmHg
- Current or recent (within last 6 months) pregnancy; current or recent (within last 3 months) breastfeeding
- Morbidly obesity (BMI \>40 kg/m\^2) or underweight (BMI \<18.5 kg/m\^2)
- Use of anti-hypertensive drugs
- Use of glucose-controlling medication
- Heavy alcohol consumption (\>15 drinks per week)
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Interventions
One 5-minute light intensity walking break per hour throughout the 4-hour SB condition
One 15-minute standing break per hour throughout the 4-hour SB condition
Two breaks per hour throughout the 4-hour SB condition, alternating between a 5-minute light intensity walking break and a 15-minute standing break
No breaks will be provided throughout the 4-hour SB condition. This will be used as the control condition
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT05316571