RecruitingNot ApplicableNCT06923397

Interrupting Sedentary Time to Improve Cardiometabolic Health and Toxicity in Patients With Lymphoma Receiving Chemotherapy: The iSTAND Trial

Sponsor

Dana-Farber Cancer Institute

Enrollment

24 participants

Start Date

Jun 5, 2025

Study Type

INTERVENTIONAL

Conditions

Lymphoma Sedentary Behavior Lymphoma, Non-Hodgkin Lymphoma, Hodgkin

Summary

This study aims to see if a 12-week exercise program designed to reduce long periods of inactivity is feasible in newly diagnosed lymphoma participants receiving R-CHOP or POLA-R-CHP chemotherapy treatments, and whether it can improve heart health and reduce chemotherapy drug side effects.

Eligibility

Min Age: 18 Years

Inclusion Criteria9

Ability to understand and the willingness to sign informed consent prior to any study- related procedures.
Patients diagnosed with lymphoma.
Will receive first line R-CHOP or POLA-R-CHP chemotherapy regimens, patients do not need to be within a certain timeframe from diagnosis.
Aged ≥18 years; due to the rarity of the disease in those \<18 years, this age bracket will not be included.
Engaging in ≤60-minutes of structured moderate or vigorous intensity exercise.
Have physician clearance to participate in exercise.
Speak English.
Willing to travel to Dana-Farber Cancer Institute for necessary data collection and exercise sessions.
Access to a phone that can receive text messages.

Exclusion Criteria5

Unstable comorbidities that prevent participation in moderate-to-vigorous intensity exercise. Patients with unstable comorbidities likely require supervised exercise for safety, and part of this study involves unsupervised exercise; therefore, for safety reasons, these persons are excluded.
Participate in more than 60 minutes of structured moderate-to-vigorous exercise per week over the last month. Excess additional exercise is a confounding factor in assessing the effect of the current interrupted sedentary time intervention.
Patients receiving treatment for other active malignancies (except basal cell carcinoma). This study is exclusively targeting lymphoma chemotherapy-related effects.
Subjects who in the opinion of the investigators may not be able to comply with the safety monitoring requirements of the study.
Unable to travel to DFCI Longwood campus for necessary data collection and chemotherapy infusions.

Interventions

BEHAVIORALInterrupted Sedentary Time Intervention

A 12-week, semi-supervised exercise intervention comprised of reminder prompts, counseling, and activities of walking, cycling, and resistance band exercise for at-home and in-clinic settings. Supervision will be under an exercise trainer. Resistance bands, Libre Pro continuous blood sugar monitor, and Fitbit and ActivPAL trackers will be provided to participants.