RecruitingNot ApplicableNCT05321316

Nectin-4 Specific LMW PET Probe Imaging in Urothelial Carcinoma

Sponsor

Peking University Cancer Hospital & Institute

Enrollment

20 participants

Start Date

May 31, 2026

Study Type

INTERVENTIONAL

Conditions

Urothelial Carcinoma

Summary

To evaluate the ability of \[68Ga\]N188 to detect nectin-4 overexpression in patients with urothelial carcinoma, especially in patients with recurrent or advanced bladder cancer.

Eligibility

Min Age: 18 YearsMax Age: 75 Years

Inclusion Criteria9

18-75 years old, male or female;
Heart function is normal;
Normal heart function;
Estimated survival ≥12 weeks;
Good follow-up compliance;
presence of at least one measurable target lesion according to RECIST1.1 criteria;
Women of childbearing age (15-49 years) must have a negative pregnancy test within 7 days before starting the test; Fertile men and women must agree to use effective contraception to prevent pregnancy during the study period and for 3 months after the test;
Patients recommended by clinicians to undergo PET/CT examination for tumor diagnostic staging;
The subject patients could fully understand and voluntarily participate in the experiment, and signed the informed consent.

Exclusion Criteria4

Serious abnormality of liver, kidney and blood;
Pregnant patients;
Pregnant and lactation women;
\) unable to lie flat for half an hour; 4) Refuse to join the clinical investigator; 5) Suffering from claustrophobia or other mental diseases; 6) Other conditions that researchers deem unsuitable for participating in the experiment.

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