Phase I/II Trial: Engineered Donor Graft (Orca Q) for Pediatric Hematopoietic Cell Transplant (HCT)

This Phase I/II study tests a specially engineered stem cell transplant product called Orca-Q in pediatric and young adult patients with blood cancers (like leukemia or lymphoma), to reduce complications like graft-versus-host disease after bone marrow transplant. **You may be eligible if...** - You are a child or young adult with a blood cancer (leukemia, lymphoma, or similar) - You need a bone marrow (stem cell) transplant - You are being treated at a participating center - A suitable donor is available **You may NOT be eligible if...** - You have severe organ dysfunction - You have an active uncontrolled infection - You have had a prior stem cell transplant (in some protocols) - You are pregnant Talk to your doctor to see if this trial is right for you.