RecruitingPhase 3NCT05323149
Tranexamic Acid in Traumatic Brain Injury
The Impact of Early Use of Tranexamic Acid in Traumatic Brain Injury Upon the Inflammatory Response and Outcome
Sponsor
Assiut University
Enrollment
60 participants
Start Date
May 18, 2022
Study Type
INTERVENTIONAL
Conditions
Summary
In this study, our aim is to investigate the role of tranexamic acid for modulating the inflammation in patients with traumatic brain injury (TBI).
Eligibility
Min Age: 18 YearsMax Age: 65 Years
Inclusion Criteria4
- Isolated traumatic brain injury patients (mild or moderate cases)
- GCS \> 8
- non penetrating TBI in 8 hours onset
- Age ≥ 18 years
Exclusion Criteria5
- Patient in cardiac arrest
- Patients with coagulopathies
- Renal failure patients
- pregnancy
- Patient refusal to participate
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Interventions
OTHERSaline
Giving saline (loading dose of 1gm of saline 0.9%, followed by a 1gm of maintenance saline dose over 8 hours for 48 h).
DRUGTranexamic acid
Giving TXA (loading dose of 1gm of TXA, followed by a 1gm of maintenance dose over 8 hours for 48 h).
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT05323149
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