Impact of Intensive Treatment of SBP on Brain Perfusion, Amyloid, and Tau (IPAT Study)

This study (IPAT Study) is testing whether intensively lowering blood pressure in older adults with high blood pressure can reduce the buildup of Alzheimer's-related proteins (amyloid and tau) in the brain and improve brain blood flow. **You may be eligible if...** - You are 60–85 years old - You have elevated blood pressure (systolic of 130 or above) and your cognition is normal or near normal - You are willing to take blood pressure medication for 2 years and return for follow-up visits - You speak English or Spanish - You have a regular healthcare provider **You may NOT be eligible if...** - You have had a stroke or significant brain disease - You have been diagnosed with Alzheimer's disease or another form of dementia - You have severe heart disease or atrial fibrillation with active symptoms - You have very poorly controlled diabetes (HbA1c above 7.5%) or use insulin - You have severe obesity (BMI over 40) or are a regular smoker - You are pregnant or could become pregnant Talk to your doctor to see if this trial is right for you.