RecruitingPhase 1Phase 2NCT05334693

Expanded Haploidentical Natural Killer Cells as Consolidation Strategy for Children/Young Adults With AML

Immunotherapy With ex Vivo Expanded Haploidentical Natural Killer Cells as Consolidation Strategy for Children/Young Adults With AML


Sponsor

Belarusian Research Center for Pediatric Oncology, Hematology and Immunology

Enrollment

15 participants

Start Date

Nov 1, 2021

Study Type

INTERVENTIONAL

Conditions

Summary

The purpose of this study is to estimate the efficacy of immunotherapy with ex vivo expanded haploidentical NK cells as consolidation therapy for children/young adults with intermediate risk AML.


Eligibility

Min Age: 6 MonthsMax Age: 21 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether infusions of special immune cells called Natural Killer (NK) cells — donated by a half-matched family member — can help prevent leukemia from coming back in children and young adults with AML (a type of blood cancer). **You may be eligible if...** - You are a child or young adult with AML (intermediate or high risk) that is currently in remission - Your cancer responded well to treatment (no detectable cancer cells) - You are generally healthy enough to function independently (performance score ≥70) - You have a half-matched (haploidentical) family member who is willing to donate immune cells **You may NOT be eligible if...** - You have an active, uncontrolled infection - Your liver function is significantly impaired - You test positive for HIV - Your potential donor is pregnant or tests positive for HIV, hepatitis B, or hepatitis C Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BIOLOGICALExpanded haploidentical NK cells

Two doses of expanded haploidentical NK cells (30-100 x 10\^6 cells /kg).


Locations(1)

Belarussian Research Center for Pediatric Oncology, Hematology and Immunology

Minsk, Minsk Oblast, Belarus

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NCT05334693


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