RecruitingNCT05336890

Post-Vent, the Sequelae: Personalized Prognostic Modeling for Consequences of Neonatal Intermittent Hypoxemia in Preterm Infants at Pre-School Age

Sponsor

Ann & Robert H Lurie Children's Hospital of Chicago

Enrollment

500 participants

Start Date

Nov 1, 2022

Study Type

OBSERVATIONAL

Conditions

Neurodevelopmental Disorders Premature Birth Asthma in Children Sleep-Disordered Breathing

Summary

Despite improved survival of extremely premature infants in recent decades, neonatal intensive care unit (NICU) graduates are diagnosed with asthma, sleep disordered breathing (SDB) in childhood, and neurodevelopmental impairments (NDI) at significant rates, disproportionate to their term peers. Early detection and intervention are critical to mitigate the impact of these impairments. Mechanisms leading from premature birth to these undesirable outcomes remain unclear, and accurate prognostic measures are lacking. This study wants to learn if these problems are related to certain patterns of breathing that babies had while they were in the NICU.

Eligibility

Min Age: 30 WeeksMax Age: 83 Months

Inclusion Criteria3

Enrolled in any Institutional Review Board (IRB) protocol of the Pre-Vent Study that had signed consent, or in any IRB protocol of the Pre-Vent Study that authorized re-contact for future research
Born \<29 weeks gestational age
Age at enrollment less than 7 years old

Exclusion Criteria6

Subject was withdrawn from the Pre-Vent study after signing Pre-Vent consent form, for any reason
Subject had no physiological data recorded as part of Pre-Vent
Lack of regulatory approval from local IRB or Department of Children and Family Services (DCFS) to recontact subjects
Adopted by non-consenting family
Parent refused further contact, prior to approach for Post-Vent
Infant enrolled in Pre-Vent at Washington University St Louis, which is not a Post-Vent participating site.