RecruitingNCT06981169

PROPULSION SANTE: Inflammometry to Improve the Diagnostic Trajectory in Situations of Suspected Asthma in Children and Adults


Sponsor

Université de Sherbrooke

Enrollment

1,500 participants

Start Date

Mar 24, 2025

Study Type

OBSERVATIONAL

Conditions

Summary

The objective of this observational study is to assess the relevance of inflammometry (based on the measurement of fractional exhaled nitric oxide (FeNO) and blood eosinophil count (BEC)) as a tool for prioritizing respiratory diagnostic tests. The study will evaluate the role of inflammometry (FeNO and BEC) in prioritizing diagnostic respiratory tests. It will include patients aged six and older with suspected asthma, referred by non-pulmonologists for diagnostic asthma testing (spirometry or methacholine challenge test) at three hospital centers: Sherbrooke University Hospital Center (CHUS), Sainte-Justine University Hospital Center (CHU Sainte-Justine), and the Montreal Children's Hospital. The hypothesis is that using inflammometry as a prioritization tool would reduce diagnostic delays for high-risk patients with elevated biomarkers. This study could help shorten wait times, relieve congestion in diagnostic testing queues, and improve the diagnostic pathway. Additionally, it would enhance the interpretation of pulmonary function test results by incorporating inflammometry findings, leading to better patient stratification. Patients referred from primary care will undergo pulmonary function testing (spirometry ± methacholine challenge) and, as part of the study: FeNO measurement using a portable device Blood test for eosinophil count Questionnaire on asthma control and quality of life, completed at the visit and at follow-ups at 4, 8, and 12 months


Eligibility

Min Age: 6 Years

Plain Language Summary

Simplified for easier understanding

This study is looking at whether measuring airway inflammation (called inflammometry — specifically measuring exhaled nitric oxide or sputum eosinophils) can improve the process of diagnosing asthma in children and adults who are being evaluated by their primary care doctor. Currently, asthma diagnosis can be uncertain, and this test may help doctors make clearer decisions. **You may be eligible if...** - You are 6 years of age or older - Your primary care doctor referred you for an asthma diagnostic test (such as spirometry or a methacholine challenge test) **You may NOT be eligible if...** - You were referred by a lung specialist (pulmonologist) rather than a primary care doctor Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIAGNOSTIC_TESTFeNO

FeNO measured with a NIOX VERO device before the respiratory test

DIAGNOSTIC_TESTblood sample

Blood sample for measuring the blood eosinophil count


Locations(3)

CHU Sainte-Justine

Montreal, Quebec, Canada

Montreal Children's Hospital

Montreal, Quebec, Canada

CIUSSS de l'Estrie - CHUS

Sherbrooke, Quebec, Canada

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NCT06981169


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