RecruitingNot ApplicableNCT05338151

Promoting Alcohol Treatment Engagement Post-hospitalization

Promoting Alcohol Treatment Engagement Post-hospitalization With Brief Intervention, Medications and CBT4CBT: A Randomized Clinical Trial in a Diverse Patient Population.


Sponsor

Yale University

Enrollment

450 participants

Start Date

Sep 13, 2022

Study Type

INTERVENTIONAL

Conditions

Summary

This study is a 3-arm randomized clinical trial to evaluate the effectiveness of hospital-initiated Alcohol Use Disorder treatment, involving a Brief Negotiated Interview (with referral and telephone booster) alone, BNI+facilitated provision of MAUD, BNI+facilitated provision of MAUD+CBT4CBT on AUD treatment engagement, alcohol use and healthcare utilization.


Eligibility

Min Age: 18 Years

Inclusion Criteria6

  • hospitalized at Yale New Haven Hospital (YNHH)
  • meet Diagnostic and Statistical Manual (DSM-5) criteria for a moderate to severe AUD (regardless of primary reason for hospitalization) consistent with clinical guidelines for MAUD initiation
  • >1 heavy drinking day by TLFB in 30 days prior to hospitalization
  • willing to consider MAUD
  • willing and able to be contacted for follow-up
  • provide written informed consent

Exclusion Criteria7

  • have been engaged in formal AUD treatment in the past 30 days (i.e., excluding mutual help groups, such as Alcoholics Anonymous)
  • meet DSM-5 criteria for untreated moderate to severe opioid use disorder
  • self-reported or urine testing confirming pregnancy, nursing, or trying to conceive
  • life-threatening or unstable medical, surgical, or psychiatric condition that prohibits study participation
  • inability to provide >1 collateral contact for a friend or family member
  • anticipate being unable to return for follow-up assessments for any reason, such as travel, incarceration, planned procedure
  • inability to understand English or Spanish.

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Interventions

BEHAVIORALBrief Negotiated Interview (BNI)

Brief Negotiated Interview (with referral and telephone booster) alone

BEHAVIORALBNI+facilitated provision of MAUD

Brief Negotiated Interview (BNI)+ Medication for Alcohol Use Disorder (MAUD)

BEHAVIORALBrief Negotiated Interview BNI+facilitated provision of MAUD+CBT4CBT

Brief Negotiated Interview (BNI)+Medication for Alcohol Use Disorder (MAUD)+Computer Based Treatment for Cognitive Behavioral Treatment (CBT4CBT)


Locations(1)

Yale New Haven Hospital

New Haven, Connecticut, United States

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NCT05338151


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