Effectiveness of Cryotherapy Combined With Compression Therapy for Preventing Chemotherapy-induced Peripheral Neuropathy

This study is testing whether wearing cold gloves and compression socks (cryotherapy + compression) during chemotherapy can prevent nerve damage in the hands and feet — a common and painful side effect called chemotherapy-induced peripheral neuropathy — in breast cancer patients. **You may be eligible if...** - You are a woman between 20 and 70 years old - You have been diagnosed with invasive breast cancer confirmed by biopsy - Your cancer is HER-2 negative - You are scheduled to receive a specific chemotherapy regimen (ddEC-ddT) - You have not had any prior cancer treatment - Your heart function (LVEF) is at least 50% - Your ECOG performance status is 0 or 1 **You may NOT be eligible if...** - You have already started chemotherapy - You are HER-2 positive - Your heart or blood counts do not meet the required thresholds Talk to your doctor to see if this trial is right for you.