RecruitingPhase 3NCT05345327
SGLT2 Inhibitors As First Line Therapy to Prevent Renal Decline in Type 2 Diabetes
Sponsor
The George Institute
Enrollment
994 participants
Start Date
Jan 1, 2023
Study Type
INTERVENTIONAL
Conditions
Summary
The aim of the trial is to evaluate the effects of the SGLT2 inhibitor, dapagliflozin, compared to metformin on annual decline in eGFR when used as first line therapy in people with Type 2 Diabetes.
Eligibility
Min Age: 18 Years
Plain Language Summary
Simplified for easier understanding
This study is testing whether SGLT2 inhibitors (a class of diabetes pill that also protects the kidneys and heart) can be used as a first-line treatment instead of metformin in people newly diagnosed with type 2 diabetes, to prevent kidney damage from the start.
**You may be eligible if...**
- You have been diagnosed with type 2 diabetes
- You are 18 years or older
- Your BMI is above 18.5
- You are either not on any diabetes medication yet, or you are only on metformin
- Your kidney function is adequate (eGFR ≥45)
**You may NOT be eligible if...**
- You urgently need intensive blood sugar control
- You have established coronary artery disease (heart attack, stents, bypass surgery) or heart failure
- You have a known reason you cannot take metformin or SGLT2 inhibitors
- Your kidney function is below the required threshold
Talk to your doctor to see if this trial is right for you.
This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.
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Interventions
DRUGDapagliflozin
SGLT2 inhibitor
DRUGMetformin
Metformin
Locations(8)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT05345327
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