RecruitingPhase 3NCT05345327

SGLT2 Inhibitors As First Line Therapy to Prevent Renal Decline in Type 2 Diabetes


Sponsor

The George Institute

Enrollment

994 participants

Start Date

Jan 1, 2023

Study Type

INTERVENTIONAL

Conditions

Summary

The aim of the trial is to evaluate the effects of the SGLT2 inhibitor, dapagliflozin, compared to metformin on annual decline in eGFR when used as first line therapy in people with Type 2 Diabetes.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether SGLT2 inhibitors (a class of diabetes pill that also protects the kidneys and heart) can be used as a first-line treatment instead of metformin in people newly diagnosed with type 2 diabetes, to prevent kidney damage from the start. **You may be eligible if...** - You have been diagnosed with type 2 diabetes - You are 18 years or older - Your BMI is above 18.5 - You are either not on any diabetes medication yet, or you are only on metformin - Your kidney function is adequate (eGFR ≥45) **You may NOT be eligible if...** - You urgently need intensive blood sugar control - You have established coronary artery disease (heart attack, stents, bypass surgery) or heart failure - You have a known reason you cannot take metformin or SGLT2 inhibitors - Your kidney function is below the required threshold Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGDapagliflozin

SGLT2 inhibitor

DRUGMetformin

Metformin


Locations(8)

The George Institute for Global Health

Sydney, New South Wales, Australia

The George Institute for Global Health

Brisbane, Queensland, Australia

Monash University

Melbourne, Victoria, Australia

National Hospital - Galle

Galle, Southern Province, Sri Lanka

National Hospital of Sri Lanka 1

Colombo, Sri Lanka

National Hospital of Sri Lanka 2

Colombo, Sri Lanka

Jaffna Teaching Hospital

Jaffna, Sri Lanka

Kandy National Hospital

Kandy, Sri Lanka

View Full Details on ClinicalTrials.gov

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NCT05345327


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