RecruitingNot ApplicableNCT05346367
Improving Therapeutic Ratio With Hypo Fractionated Stereotactic Radiotherapy for Brain Metastases
Sponsor
Haaglanden Medical Centre
Enrollment
130 participants
Start Date
Jul 18, 2022
Study Type
INTERVENTIONAL
Conditions
Summary
Randomized phase II trial. The study aims to investigate a different and potentially safer radio therapeutic treatment method for brain metastases. The current standard of stereotactic radiotherapy (SRT) in one or three fractions is compared to fractionated stereotactic radiotherapy (fSRT) in five fractions.
Eligibility
Min Age: 18 Years
Inclusion Criteria6
- Age ≥ 18 years
- At least one brain metastasis of large cell cancer suitable for SRT
- Karnofsky Performance Status ≥ 70
- Ability to provide written informed consent
- New brain metastases during follow-up after surgery allowed (when outside of resection cavity area)
- New brain metastases during follow-up after previous SRT allowed (when outside of previous irradiation field)
Exclusion Criteria5
- Contra-indication for MRI scan
- Primary tumor of small cell lung cancer, germinoma or lymphoma
- Prior whole brain radiotherapy or SRT on the current target brain metastases (in field re-irradiation)
- Presence of leptomeningeal metastases
- Previous inclusion in the SAFESTEREO study
Interventions
RADIATIONSRT
SRT
RADIATIONfSRT
fSRT
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT05346367
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