Improving Therapeutic Ratio With Hypo Fractionated Stereotactic Radiotherapy for Brain Metastases

This study is testing a type of focused, high-precision radiation therapy (called stereotactic radiotherapy, or SRT) for brain tumors that have spread from cancer elsewhere in the body. It aims to find the best radiation dose schedule to treat the tumors effectively while minimizing side effects. **You may be eligible if...** - You are 18 or older - You have at least one brain metastasis from a large cell cancer that is suitable for SRT - Your general health and functioning are reasonably good (Karnofsky score of 70 or higher) - New brain metastases appearing after prior surgery or radiation (in a different area) are allowed **You may NOT be eligible if...** - You have a contraindication to MRI scanning - Your primary cancer is small cell lung cancer, a germ cell tumor, or lymphoma - You have previously had whole-brain radiation or SRT to the exact same brain area being treated now - You have cancer spread to the lining of the brain (leptomeningeal disease) - You previously participated in the SAFESTEREO study Talk to your doctor to see if this trial is right for you.