Laser Interstitial Thermal Therapy (LITT) or Surgery and Adjuvant Reirradiation for Recurrent Brain Metastases (LaSAR BeaM)

Inclusion Criteria11

• Ability to understand and the willingness to sign a written informed consent document.
• Willingness to comply with all study procedures and availability for the duration of the study.
• Age ≥18 years. Because no dosing or adverse event data are currently available on the use of SRS2, children are excluded from this study.
• Karnofsky performance status ≥ 60.
• Radiographic concern for progression of a solid tumor brain metastasis that has received prior stereotactic radiosurgery ≥ 3 months prior to study enrollment.
• Patients must have measurable disease, defined as at least one lesion that can be accurately measured in at least one dimension as ≥5 mm with MRI scan.
• Have active tumor on pathology from surgery/LITT for this lesion.
• Able to safely undergo MRI imaging.
• Acceptable candidate for SRS2 per treating physician and multidisciplinary conference consensus.
• Have no radiographic evidence of leptomeningeal disease on radiology report or neuro-radiologist review.
• Patients with a prior or concurrent malignancy whose natural history or treatment does not interfere with the safety or efficacy assessment of the investigational regimen are eligible for this trial.