FMISO-based Adaptive Radiotherapy for Head and Neck Cancer

This study is testing a new way to deliver radiation therapy for certain head and neck cancers by using a special imaging scan (FMISO PET) to identify the most oxygen-starved (and hardest to treat) areas within the tumor, then targeting those spots with higher radiation doses. This approach aims to improve treatment outcomes. **You may be eligible if...** - You have a newly diagnosed, stage III or IV squamous cell cancer of the throat, voice box, mouth, or a related area - You have not yet had surgery, radiation, or systemic therapy for this cancer - Your kidney and liver function are adequate - You are able to carry out normal daily activities (ECOG performance status 0 or 1) **You may NOT be eligible if...** - You have already had surgery or prior radiation/chemotherapy for this cancer - Your cancer is in the nose, sinuses, or is from an unknown primary - The cancer has spread to other parts of your body beyond the head and neck - You have active HIV, Hepatitis B or C - You have had a previous blood cancer or solid tumor (unless in remission for at least 5 years) Talk to your doctor to see if this trial is right for you.