RecruitingPhase 2NCT05350891
Transnasal Endoscopic Surgery Combined With Adjuvant Immunotherapy for Recurrent NPC
A Prospective, Single-arm, Multicenter Clinical Study of Transnasal Endoscopic Surgery Combined With Adjuvant Immunotherapy for Recurrent Nasopharyngeal Carcinoma
Sponsor
Eye & ENT Hospital of Fudan University
Enrollment
77 participants
Start Date
May 8, 2022
Study Type
INTERVENTIONAL
Conditions
Summary
A Prospective, Single-arm, Multicenter Clinical Study of Transnasal Endoscopic Surgery Combined With Adjuvant Immunotherapy for Recurrent Nasopharyngeal Carcinoma
Eligibility
Min Age: 18 Years
Inclusion Criteria9
- Pathology or radiography confirmed recurrent nasopharyngeal carcinoma.
- AJCC rT1-T4 which can be surgically removed.
- Age ≥18 years old.
- Informed consent signed.
- With or without lymph node metastasis, which can be surgically removed.
- No distant metastasis.
- ≥6 months from the end of initial radiotherapy to recurrence.
- Sufficient organ function a)Hematology: white blood cells ≥3.0 x 109/L, absolute neutrophil count ≥1.5x 109/L, hemoglobin ≥80 g/L, platelets ≥100 x 109/L. b) Liver function: bilirubin ≤ 1.5 times the upper limit of normal (ULN), AST and ALT ≤ 3 times the ULN c) International normalized ratio (INR) or prothrombin time (PT) or activated partial thromboplastin time (aPTT) ≤ 1.5 times ULN. d) Renal function: serum creatinine ≤ 1.5 times ULN.
- ECOG score 0-2. general physical condition can tolerate general anesthesia surgery, chemotherapy, and immunotherapy.
Exclusion Criteria16
- Evidence of distant metastasis or leptomeningel disease (LMD).
- Have received radioactive seed implantation in the treatment area.
- Suffer from uncontrolled disease which could interfere with treatment.
- Suffered from another malignant tumor or multiple primary tumors at the same time within 5 years (excluding fully treated basal cell or squamous cell skin cancer, cervical cancer in situ, etc.).
- The patient has surgical contraindications: such as severe cardiopulmonary disease, coagulation dysfunction and so on.
- The patients have autoimmune diseases.
- The patient is using immunosuppressive agents or systemic glucocorticoid to achieve the purpose of immunosuppression (dose\>10mg/day prednisone or other), and continues to use it within 2 weeks before the first administration.
- Severe allergic reaction to other monoclonal antibodies.
- Previously received PD-1 monoclonal antibody, CTLA-4 monoclonal antibody (or any other antibody that acts on T cell co-stimulation or checkpoint pathway) treatment.
- Live vaccines have been inoculated within 4 weeks before the first administration or during the study period.
- The patient has any situation that may hinder study compliance or the safety during the study period.
- Existence of serious neurological or psychiatric diseases, such as dementia and seizures.
- Uncontrolled active infection.
- Pregnant or breastfeeding women.
- Those who have no personal freedom and independent capacity for civil conduct.
- There are other situations that are not suitable for entry into the study.
Interventions
PROCEDUREendoscopic surgery
endoscopic surgery combined with adjuvant immunotherapy with/without chemotherapy
Locations(8)
View Full Details on ClinicalTrials.gov
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NCT05350891
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