Patient-tailored Transcranial Direct Current Stimulation to Improve Stroke Rehabilitation

Exclusion Criteria21

• \>50% stenosis of extra- or intracranial artery as well as vascular malformations or aneurisms detected by brain CT-angiography.
• Exclusively ischemic stroke in spine, pons, brainstem, medulla or cerebellum.
• History of seizures, epilepsy, anxiety, dementia alcohol- or drug abuse.
• Prior serious head injury or neurosurgery
• Frequent severe headaches or migraine.
• Pregnancy or breastfeeding
• Current use of neuro-receptor/transmitter modulating medication, or medication interfering with seizure threshold (such as antiepileptic medication, some antidepressants, anxiety medication, antihistamines, stimulant drugs for attention deficit hyperactivity disorder).
• Pacemaker, implantable cardiac device unit (ICD-unit), metal fragments or other materials implanted not compatible with MRI (see appendix B).
• Claustrophobia
• Prior adverse effect to TDCS or Transcranial Magnetic Stimulation.
• Not able to provide informed consent.
• Terminally ill or short life expectancy.
• History of neurologic disease
• History of cerebral haemorrhage or brain damage
• Pregnancy
• Pacemaker or other implanted electronic devices
• Claustrophobia
• Psychiatric disorder
• Epilepsy or close relatives suffering from epilepsy
• Migraine
• Any contraindication to MRI or TMS