RecruitingNot ApplicableNCT05355831

Patient-tailored Transcranial Direct Current Stimulation to Improve Stroke Rehabilitation

Sponsor

Christina Kruuse

Enrollment

22 participants

Start Date

Aug 28, 2022

Study Type

INTERVENTIONAL

Conditions

Ischemic Stroke Upper Extremity Hemiparesis

Summary

In a double-blinded sham-controlled study the effect of patient-tailored transcranial direct current stimulation during rehabilitation training will be examined.

Eligibility

Min Age: 18 Years

Inclusion Criteria14

Age >18 years
Ischemic stroke confirmed by clinical and imaging criteria
Hemiparesis including reduced upper-extremity function
Location of stroke either cortically involving middle cerebral artery or the anterior cerebral artery circulation or subcortical (involving thalamus, basal ganglia).
NIHSS score >2 and <8
Modified Rankin Scale (mRS) ≤ 3
Index of stroke within 4 weeks of inclusion
Signed informed consent
Age between >18 years (matched to patients)
Sex and age matched to patients
Able bodied
Have the ability to comply with all requirements of the study protocol, as determined by the investigator
No history of stroke or dementia
Eligible for MRI and TMS

Exclusion Criteria21

>50% stenosis of extra- or intracranial artery as well as vascular malformations or aneurisms detected by brain CT-angiography.
Exclusively ischemic stroke in spine, pons, brainstem, medulla or cerebellum.
History of seizures, epilepsy, anxiety, dementia alcohol- or drug abuse.
Prior serious head injury or neurosurgery
Frequent severe headaches or migraine.
Pregnancy or breastfeeding
Current use of neuro-receptor/transmitter modulating medication, or medication interfering with seizure threshold (such as antiepileptic medication, some antidepressants, anxiety medication, antihistamines, stimulant drugs for attention deficit hyperactivity disorder).
Pacemaker, implantable cardiac device unit (ICD-unit), metal fragments or other materials implanted not compatible with MRI (see appendix B).
Claustrophobia
Prior adverse effect to TDCS or Transcranial Magnetic Stimulation.
Not able to provide informed consent.
Terminally ill or short life expectancy.
History of neurologic disease
History of cerebral haemorrhage or brain damage
Pregnancy
Pacemaker or other implanted electronic devices
Claustrophobia
Psychiatric disorder
Epilepsy or close relatives suffering from epilepsy
Migraine
Any contraindication to MRI or TMS