Survival, Quality of Life and Resectability in Locally Advanced Pancreatic Cancer

This study is following and collecting data on people with locally advanced pancreatic cancer — tumors that have grown into nearby blood vessels or tissue but have not yet spread to distant organs — to understand which patients benefit most from surgery, chemotherapy, or other treatment combinations. **You may be eligible if...** - You have a confirmed or suspected invasive pancreatic cancer - Your tumor is classified as borderline resectable or locally advanced (meaning it may or may not be operable) according to standard oncology guidelines - You are 18 or older **You may NOT be eligible if...** - Your tumor is a pancreatic endocrine (hormone-producing) tumor rather than the common type - You have cancer arising near the pancreas but not within the pancreas itself (non-pancreatic periampullary tumor) - Your cancer has spread to distant organs (e.g., liver, lungs) - You are unable to understand or consent to participation due to language, mental, or cognitive barriers Talk to your doctor to see if this trial is right for you.